Recognition of IOB papers by DST
Molecular Biology Lab
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  Department of Biotechnology, Government of India provided a grant support to Institute of Bioinformatics and NIMHANS to carry out proteomic investigation to analyze neurological diseases.
  IOB is recognized as a research center for award of Ph.D. degrees with Manipal University.
  IOB is recognized as a research center for award of Ph.D. degrees with Kuvempu University.
  IOB is recognized as a research center for award of Ph.D. degrees with Amrita University.
  IOB is recognized as a research center for award of Ph.D. degrees with Pondicherry University.


The Team

Barocycler NEP2320


Research Lab


TSQ Quantam Ultra Mass Spectrometer


LTQ Orbitrap Velos Mass Spectrometer

Human Proteinpedia: IOB scientists create the largest community resource of experimental data in human proteins. It is a portal for sharing and integration of human protein data. The international collaborative work is published in February issue of Nature Biotechnology.
Resource of Asian Primary Immunodeficiency Disease (RAPID): IOB Scientists have developed database of Primary Immunodeficiency Disease genes known as 'Resource of Asian Primary Immunodeficiency Disease (RAPID)' in collabration with RIKEN, Japan. We have also developed algorithm for the prediction of candidate primary Immunodeficiency disease genes using support vector machine learning approach Results of these studies have been published in 'Nucleic Acids Research' and 'DNA Research ' respectively.

Molecular profiling of Embryonic Stem Cells and Embryonic Carcinoma Cells: Scientists from IOB and Pandey lab have identified key molecules that differentiate embryonic stem cells from embryonic carcinoma cells by quantitative proteomics. The findings from the above study was published in the journal Proteomics.

Investigation of Molecular Markers of Neuronal Differentiation: Using advanced labeling technology, molecular markers of differentiation of motor neurons and astrocytes from embryonic stem cells were identified in a collaborative study between IOB, Pandey lab and Institute of Cell Engineering, Johns Hopkins University Findings from this study are published in Journal of Proteome Research.
Quantitative Proteomic Investigation of Hepatocellular Carcinoma: IOB scientists unveil the first large scale quantitative proteomic profiling of hepatocellular carcinoma using robust discovery platforms such as iTRAQ labeling and high resolution mass spectrometry. The study revealed several novel and known upregulated proteins as potential biomarkers in hepatocellular carcinoma and results are published Journal of Proteome Research.
Gene expression studies in Esophageal Squamous Cell Carcinoma: Scientists at IOB used a combination of DNA microarrays and immunohistochemical labeling of tissue microarrays to delineate gene expression patterns in cancer of esophagus and subsequently to validate molecular signatures specific to this cancer. Results of this investigation are published in Cancer Biology and Therapy.
IOB scientists assemble and analyze the largest interactome in humans: The 'circuitry' in human cells was analyzed by IOB scientists and published in Nature Genetics.

IOB mapped the human proteome for the first time:
Researchers from the Institute of Bioinformatics, Bangalore, as part of a 72-member team, have for the first time deciphered a near complete protein map of human beings. Results from this landmark study is featured on the cover of the prestigious journal Nature  
NDTV coverage on the Human Proteome Map

Click here to view more news articles on Human Proteome Map

IOB's contribution to the India's Research Landscape:
The Department of Science and Technology (DST), Government of India published "India's Research Landscape: Output, Collaboration and Comparative Performance - Bibliometric Studies" on February 17, 2016, which consisted of two reports. First report compiled by Thomson Reuters and entitled "India's Research Output and Collaboration (2005-14): A Bibliometric Study" while the other report was independently compiled by Elsevier and entitled "International Comparative Performance of India's Research Base (2009-14)." In Thomson Reuters report "Human Protein Reference Database" paper published in the year 2009 is ranked second among the Top 10 Publications with Indian Affiliation in the area of Biology and Biochemistry and "A draft map of human proteome" featured on the cover of Nature in 2014, was found to be cited more than 400 times within a short span and is ranked sixth.

In Elsevier report Human Protein Reference Database" is ranked second in the area of Biochemistry, Genetics and Molecular Biology with 1,029 citations.

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