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: IOB Scientists
have developed database of Primary Immunodeficiency Disease genes
known as 'Resource of Asian Primary Immunodeficiency Disease (RAPID)'
in collabration with RIKEN, Japan. We have also developed algorithm
for the prediction of candidate primary Immunodeficiency disease
genes using support vector machine learning approach Results of these
studies have been published in 'Nucleic
Acids Research' and 'DNA
Research' respectively.
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Molecular profiling of Embryonic Stem Cells and Embryonic
Carcinoma Cells: Scientists from IOB and
Pandey lab have identified key molecules that differentiate embryonic
stem cells from embryonic carcinoma cells by quantitative proteomics.
The findings from the above study was published in the journal Proteomics.
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Investigation of Molecular
Markers of Neuronal Differentiation: Using advanced labeling
technology, molecular markers of differentiation of motor neurons and
astrocytes from embryonic stem cells were identified in a collaborative
study between IOB, Pandey lab and Institute of Cell Engineering, Johns
Hopkins University Findings from this study are published in Journal
of Proteome Research.
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Quantitative Proteomic Investigation
of Hepatocellular Carcinoma: IOB scientists unveil the first
large scale quantitative proteomic profiling of hepatocellular carcinoma
using robust discovery platforms such as iTRAQ labeling and high resolution
mass spectrometry. The study revealed several novel and known upregulated
proteins as potential biomarkers in hepatocellular carcinoma and results
are published Journal of Proteome Research.
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