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Ravi Sirdeshmukh, Ph.D.
Associate Director & Distinguished Scientist |
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Institute of Bioinformatics
Discoverer Building, International Tech Park, Whitefield
Bangalore - 560 066
E-mail: ravi at ibioinformatics dot org
Phone: +91-80-28416140 Fax: +91-80-28416132 |
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| Education |
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Ph.D. in Biochemistry, Centre for Cellular and Molecular Biology, Hyderabad, India |
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M.Sc. in Biochemistry, Osmania University, Hyderabad, India |
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Positions Held |
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Associate Director & Distinguished Scientist, Institute of Bioinformatics, Bangalore, India, 2010-Present |
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Scientist G, Center for Cellular and Molecular Biology, Hyderabad, India 2007-2009 |
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Scientist F, Center for Cellular and Molecular Biology, Hyderabad, India 2002-2007 |
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Visiting Scientist, National Cancer Institute, National Institutes of Health, MD, USA 2006 |
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Scientist E-II, Center for Cellular and Molecular Biology, Hyderabad, India 1996-2002 |
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Scientist E1, Center for Cellular and Molecular Biology, Hyderabad, India 1992-1996 |
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Visiting Scientist, National Institute of Neurological Disorders and Stroke, NIH, USA 1996 |
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Scientist C, Center for Cellular and Molecular Biology, Hyderabad, India 1987-1992 |
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Post Doctoral Fellow, Washington University Medical School, St Louis, USA 1982-1987 |
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Area of Specialization |
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Proteomics |
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Transcriptomics |
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Oncology |
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Publications |
Research papers: 32 |
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Pawar, H., Maharudraiah, J., Kashyap, M.
K., Sharma, J., Srikanth, M. S., Choudhary, R., Chavan,
S., Sathe, G., Manju, H .C., Veerendra Kumar, K. V.,
Vijayakumar, M., Sirdeshmukh, R., Harsha, H. C., Prasad,
T. S. K., Pandey, A. and Kumar, R. V. (2012). Downregulation
of cornulin in esophageal squamous cell carcinoma. Acta
Histochemica. In press.
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Polisetty, R. V., Gautam, P., Sharma, R.,
Harsha, H. C., Nair, S. C., Gupta, M. K., Uppin, M. S.,
Challa, S., Puligopu, A. K., Ankathi, P., Purohit, A.
K., Chandak, G. R., Pandey, A. and Sirdeshmukh,
R. (2012).
LC-MS/MS Analysis of Differentially Expressed Glioblastoma
Membrane Proteome Reveals Altered Calcium Signalling
and other Protein Groups of Regulatory Functions. Molecular
and Cellular Proteomics. [PubMed]
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Gautam, P., Upadhyay, S. K., Hassan, W.,
Madan, T., Sirdeshmukh, R., Sundaram,
C. S., Gade, W. N., Basir, S. F., Singh, Y. and Sarma,
P. U. Transcriptomic and proteomic profile of Aspergillus
fumigatus on exposure to artemisinin. Mycopathologia.
2011. 172, 331-346. [PubMed]
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Polisetty, R. V., Gupta, M. K., Nair, S.
C., Ramamoorthy, K., Tiwary, S., Shiras, A., Chandak,
G. R. and Sirdeshmukh,
R. Glioblastoma cell secretome: analysis of
three glioblastoma cell lines reveal 148 non-redundant
proteins. Journal
of Proteomics. 2011. 74, 1918-1925. [PubMed]
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Peng, L., Kapp, E. A., Fenyo, D., Kwon, M. S., Jiang, P., Wu, S., Jiang, Y., Aguilar, M. I., Ahmed, N., Baker, M. S., Cai, Z., Chen, Y. J., Van, C. h. i., Chung, M. C., He, F., Len, A. C., Liao, P. C., Nakamura, K., Ngai, S. M., Paik, Y. K., Pan, T. L., Poon, T. C., Salekdeh, G. H., Simpson, R. J., Sirdeshmukh, R., Srisomsap, C., Svasti, J., Tyan, Y. C., Dreyer, F. S., McLauchlan, D., Rawson, P. and Jordan, T. W. The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of the carbonate-washed membrane standard. Proteomics. 2010. 10, 4142-4148. [PubMed]
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Govekar, R. B., D'Cruz, A. K., Alok, P., Agarwal, J., Dinshaw, K. A., Chinoy, R. F., Gadewal, N., Kannan, S., Sirdeshmukh, R., Sundaram, C. S., Malgundkar, S. A., Kane, S. V. and Zingde, S. M. Proteomic profiling of cancer of the gingivo-buccal complex: Identification of new differentially expressed markers. Proteomics - Clinical Applications. 2009. 3, 1451-1462. [PubMed]
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Gautam, P., Shankar, J., Madan, T., Sirdeshmukh, R., Sundaram, C. S., Gade, W. N., Basir, S. F. and Sarma, P. U. Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B. Antimicrobial Agents and Chemotherapy. 2008. 52, 4220-4227. [PubMed]
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Sirdeshmukh R. Proteomics in India: an overview. Molecular & Cellular Proteomics. 2008. 7, 1406-1407. [PubMed] |
Mathivanan, S., Ahmed, M., Ahn, N. G., Alexandre, H., Amanchy, R., Andrews, P. C., Bader, J. S., Balgley, B. M., Bantscheff, M., Bennett, K. L., Bjorling, E., Blagoev, B., Bose, R., Brahmachari, S. K., Burlingame, A. S., Bustelo, X. R., Cagney, G., Cantin, G. T., Cardasis, H. L., Celis, J. E., Chaerkady, R., Chu, F., Cole, P. A., Costello, C. E., Cotter, R. J., Crockett, D., DeLany, J. P., De, M., DeSouza, L. V., Deutsch, E. W., Dransfield, E., Drewes, G., Droit, A., Dunn, M. J., Elenitoba-Johnson, K., Ewing, R. M., Van, E. y. k., Faca, V., Falkner, J., Fang, X., Fenselau, C., Figeys, D., Gagne, P., Gelfi, C., Gevaert, K., Gimble, J. M., Gnad, F., Goel, R., Gromov, P., Hanash, S. M., Hancock, W. S., Harsha, H. C., Hart, G., Hays, F., He, F., Hebbar, P., Helsens, K., Hermeking, H., Hide, W., Hjerno, K., Hochstrasser, D. F., Hofmann, O., Horn, D. M., Hruban, R. H., Ibarrola, N., James, P., Jensen, O. N., Jensen, P. H., Jung, P., Kandasamy, K., Kheterpal, I., Kikuno, R. F., Korf, U., Korner, R., Kuster, B., Kwon, M. S., Lee, H. J., Lee, Y. J., Lefevre, M., Lehvaslaiho, M., Lescuyer, P., Levander, F., Lim, M. S., Lobke, C., Loo, J. A., Mann, M., Martens, L., Martinez-Heredia, J., McComb, M., McRedmond, J., Mehrle, A., Menon, R., Miller, C. A., Mischak, H., Mohan, S. S., Mohmood, R., Molina, H., Moran, M. F., Morgan, J. D., Moritz, R., Morzel, M., Muddiman, D. C., Nalli, A., Navarro, J. D., Neubert, T. A., Ohara, O., Oliva, R., Omenn, G. S., Oyama, M., Paik, Y. K., Pennington, K., Pepperkok, R., Periaswamy, B., Petricoin, E. F., Poirier, G. G., Prasad, T. S., Purvine, S. O., Rahiman, B. A., Ramachandran, P., Ramachandra, Y. L., Rice, R. H., Rick, J., Ronnholm, R. H., Salonen, J., Sanchez, J. C., Sayd, T., Seshi, B., Shankari, K., Sheng, S. J., Shetty, V., Shivakumar, K., Simpson, R. J., Sirdeshmukh, R., Siu, K. W., Smith, J. C., Smith, R. D., States, D. J., Sugano, S., Sullivan, M., Superti-Furga, G., Takatalo, M., Thongboonkerd, V., Trinidad, J. C., Uhlen, M., Vandekerckhove, J., Vasilescu, J., Veenstra, T. D., Vidal-Taboada, J. M., Vihinen, M., Wait, R., Wang, X., Wiemann, S., Wu, B., Xu, T., Yates, J. R., Zhong, J., Zhou, M., Zhu, Y., Zurbig, P. and Pandey, A. Human Proteinpedia enables sharing of human protein data. Nature Biotechnology. 2008. 26, 164-167. [PubMed]
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Shukla, S., Govekar, R. B., Sirdeshmukh, R., Sundaram, C. S., D'Cruz, A. K., Pathak, K. A., Kane, S. V. and Zingde, S. M. Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex. Proteomics - Clinical Applications. 2007. 1, 1592-1604. [PubMed]
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Suhasini, A. N. and Sirdeshmukh, R. Onconase action on tRNA(Lys3), the primer for HIV-1 reverse transcription. Biochemical and Biophysical Research Communications. 2007. 363, 304-309. [PubMed]
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Gautam, P., Sundaram, C. S., Madan, T., Gade, W. N., Shah, A., Sirdeshmukh, R. and Sarma, P. U. Identification of novel allergens of Aspergillus fumigatus using immunoproteomics approach. Clinical and Experimental Allergy : Journal of the British Society for Allergy. 2007. 37, 1239-1249. [PubMed]
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Sirdeshmukh R. Fostering proteomics in India. Journal of Proteome Research. 2006. 5, 2879. [PubMed]
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Sharma, S., Sundaram, C. S., Luthra, P. M., Singh, Y., Sirdeshmukh, R. and Gade, W. N. Role of proteins in resistance mechanism of Pseudomonas fluorescens against heavy metal induced stress with proteomics approach. Journal of Biotechnology. 2006. 126, 374-382. [PubMed]
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Suhasini, A. N. and Sirdeshmukh, R. Transfer RNA cleavages by onconase reveal unusual cleavage sites. The Journal of Biological Chemistry. 2006. 281, 12201-12209. [PubMed]
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Chumbalkar, V. C., Subhashini, C., Dhople, V. M., Sundaram, C. S., Jagannadham, M. V., Kumar, K. N., Srinivas, P. N., Mythili, R., Rao, M. K., Kulkarni, M. J., Hegde, S., Hegde, A. S., Samual, C., Santosh, V., Singh, L. and Sirdeshmukh, R. Differential protein expression in human gliomas and molecular insights. Proteomics. 2005. 5, 1167-1177. [PubMed]
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Chandra, H., Gupta, P. K., Sharma, K., Mattoo, A. R., Garg, S. K., Gade, W. N., Sirdeshmukh, R., Maithal, K. and Singh, Y. Proteome analysis of mouse macrophages treated with anthrax lethal toxin. Biochimica et Biophysica Acta. 2005. 1747, 151-159. [PubMed]
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Saxena, S. K., Sirdeshmukh, R., Ardelt, W., Mikulski, S. M., Shogen, K. and Youle, R. J. Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. The Journal of Biological Chemistry. 2002. 277, 15142-15146. [PubMed]
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Murthy, B. S., De, L., Piccoli, R., D'Alessio, G. and Sirdeshmukh, R. Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase. Biochemistry. 1996. 35, 3880-3885. [PubMed]
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Tharun, S. and Sirdeshmukh, R. Specific endonucleolytic cleavages of mouse albumin mRNA and their modulation during liver development. Nucleic Acids Research. 1995. 23, 641-646. [PubMed]
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Rao, K. S., Sirdeshmukh, R. and Gupta, P. D. Modulation of cytosolic RNase activity by endogenous RNase inhibitor in rat vaginal epithelial cells on estradiol administration. FEBS Letters. 1994. 343, 11-14. [PubMed]
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Murthy, B. S. and Sirdeshmukh, R. Sensitivity of monomeric and dimeric forms of bovine seminal ribonuclease to human placental ribonuclease inhibitor. The Biochemical Journal. 1992. 281 ( Pt 2), 343-348. [PubMed]
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Krych, M., Sirdeshmukh, R., Gourse, R. and Schlessinger, D. Processing of Escherichia coli 16S rRNA with bacteriophage lambda leader sequences. Journal of Bacteriology. 1987. 169, 5523-5529. [PubMed]
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Schlessinger, D., Thomas, J. R., Krych, M., Sirdeshmukh, R. and Little, R. D. Ribosomal RNA processing in Escherichia coli and cultured mammalian cells. Biochemical Society Transactions. 1986. 14, 811-813. [PubMed]
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Sirdeshmukh, R. and Schlessinger, D. Why is processing of 23 S ribosomal RNA in Escherichia coli not obligate for its function? Journal of Molecular Biology. 1985. 186, 669-672. [PubMed]
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Sirdeshmukh, R. and Schlessinger, D. Ordered processing of Escherichia coli 23S rRNA in vitro. Nucleic Acids Research. 1985. 13, 5041-5054. [PubMed]
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Schlessinger, D., Bolla, R. I., Sirdeshmukh, R. and Thomas, J. R. Spacers and processing of large ribosomal RNAs in Escherichia coli and mouse cells. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 1985. 3, 14-18. [PubMed]
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Sirdeshmukh, R., Krych, M. and Schlessinger, D. Escherichia coli 23S ribosomal RNA truncated at its 5' terminus. Nucleic Acids Research. 1985. 13, 1185-1192. [PubMed]
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Sirdeshmukh, R., Vijayarangam, D. and Bhargava, P. M. E. coli RNA entrapped in large unilamellar liposomes is partially exposed. Indian Journal of Biochemistry & Biophysics. 1984. 21, 293-298. [PubMed]
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King, T. C., Sirdeshmukh, R. and Schlessinger, D. RNase III cleavage is obligate for maturation but not for function of Escherichia coli pre-23S rRNA. Proceedings of the National Academy of Sciences of the United States of America. 1984. 81, 185-188. [PubMed]
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Sirdeshmukh, R. B. and Bhargava, P. M. Uptake of exogenous RNA by rat-liver parenchymal cells in suspension prepared by the collagenase method. Indian Journal of Biochemistry & Biophysics. 1983. 20, 121-126. [PubMed]
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Sirdeshmukh, R. and Bhargava, P. M. Evidence for the presence of a cell-surface ribonuclease in mechanically prepared rat-liver cells in suspension. Bioscience Reports. 1982. 2, 751-760. [PubMed]
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Research Support |
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Title of Project |
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Funding Agency |
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Role |
| 1 |
Identification of new biomarkers using genomics and proteomics |
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Council of Scientific and Industrial Research, Government of India |
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PI |
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Proteomics of the effect of alkylating agents on mouse liver |
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Defence Research and Development Organisation, New Delhi, India |
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PI |
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New insights in cancer biology- Proteomics of glioma |
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Council of Scientific and Industrial Research, Government of India |
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PI |
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Plasma proteomics for health and disease |
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Council of Scientific and Industrial Research, Government of India |
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PI |
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Medically important fungus Aspergillus fumigatus |
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Department of Science & Technology, Government of India |
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Co-PI |
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Identification and functional analysis of genes for yield in rice |
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Department of Biotechnology, Government of India |
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Co-PI |
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| Member |
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SAC, Institute Of Cytology and Preventive Medicine, ICMR, Noida |
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Program Advisory Committee, National Facility for Advanced Proteomics and Protein Research, IICB, Kolkata |
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SAC, Institute of Pathology, ICMR, New Delhi |
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Board of Studies in Biotechnology, Osmania University, Hyderabad |
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2007-2008, Consortium manager of CSIR Proteomics Network for International Collaborations |
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Nodal scientist, EFYP CSIR Plasma Proteomics Network Project |
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Invited/elected member of the Council of Human Proteome Organization
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Invited member of the Council of Asian Oceanean HUPO |
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Advisory Panel for Protein and Glycoprotein analysis, US Pharmacopeia, USA |
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Editorial Board Member - Journal of Proteomics and Bioinformatics |
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Reviewer - Proteomics, Annals of Neurology, Proteomics - Clinical Applications, Journal of Proteome Research |
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