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There is a large amount of data pertaining to proteins that is
being generated in laboratories all over the world, which needs
to be classified in a systematic manner and available in a format
that facilitates easier reading and interpretation. This necessitates
development of protein databases to make such data accessible to
the investigators on a common platform. The Human Protein Reference
Database (HPRD), the pioneer project of the Institute of Bioinformatics
– a first of its kind biological database, comprehending all
relevant data pertaining to human proteins and diseased genes. |
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The project uses open source technologies and is freely available
to the public. It uses a completely object orientated design, the
first of its kind in biological databases. Another unique approach
of HPRD is the use of SVG (Scalable Vector Graphics) to optimally
visualize protein - protein interaction data. We employ DAS (Distributed
Annotation System) to enrich our annotations by allowing experts in
specialized domain to review the proteins that are annotated in our
Database.
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| The Database currently
hosts nearly 25000 annotations including, over 33000 Interactions,
14000 PTMs and 16000 Substrates. The information provided in the Database
is manually extracted from published articles and has undergone several
levels of curation before made publicly available. The database
will host annotations of all the known human proteins and update them on
an ongoing basis. The database is published in the October 2003 issue of
Genome Research, January 2004 issue of Nucleic Acid Research and January 2006
issue of Nucleic Acid Research. |
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