Institute of Bioinformatics

Aditi Chatterjee, Ph.D.
Faculty Scientist

Institute of Bioinformatics
Discoverer Building, International Tech Park, Whitefield
Bangalore - 560 066
E-mail: aditi at ibioinformatics dot org
Phone: +91-80-28416140 Fax: +91-80-28416132

Education

	Ph.D. in Biochemistry, University College of Science, Department of Biochemistry, Calcutta, India, 2001.
	M.Sc. in Biochemistry, University College of Science, Department of Biochemistry, Calcutta, India, 1995.

Positions Held

	Faculty Scientist, Institute of Bioinformatics, Bangalore, July 2011 – present.
	Instructor, Department of Otolaryngology, Johns Hopkins University, School of Medicine Baltimore, MD, USA, April 2008 – June 2011.
	Senior Postdoctoral Research Fellow, Department of Otolaryngology; Johns Hopkins University, School of Medicine, Baltimore, MD, USA, February 2006 – March 2008.
	Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore, July 2005 – February 2006.
	Postdoctoral Research Fellow, Department of Otolaryngology, Johns Hopkins University, School of Medicine Baltimore, MD, USA, July 2002 – July 2005.
	Postdoctoral Research Fellow, Department of Oncology, Johns Hopkins University, School of Medicine Baltimore, MD, USA, September 2000– June 2002.
	Summer Internship, University of Minnesota, Twin Cities, Saint Paul, MN, USA, August 1998 - May 1999.
	Graduate Student, Research fellow in Biochemistry, University of Calcutta, Department of Biochemistry Calcutta, India. December 1995 –August 2000.

Honors and Awards

	Recipient of 2007 Young Clinical Scientist Award from Flight Attendant Medical Research Institute. (for 2008-2011).
	Judged as the best speaker at Young Scientists Symposium on Frontiers of Reproductive Biology, Hyderabad, India. (1996)

Area of Specialization

	Cancer Biology/Molecular Biology
	Signaling pathway
	miRNA in cancer
	Proteomics

Biography

Dr. Aditi Chatterjee has investigated the role of cigarette smoke in the induction of chemotherapeutic resistance in bladder cancer using miRNA profiling approaches. She has also studied mitochondrial damage and repair in various cancers to decipher molecular mechanisms involved in DNA repair. She is the Senior Guest Editor for the Journal of Oncology for a special issue on Cigarette Smoke and Cancer. She has been a reviewer for PLOS One, Journal of Proteomics, FEBS Letters and Hematological Oncology. Currently, she is carrying out whole genome sequencing and phosphoproteomic profiling of gallbladder cancer. She is also studying the effect of cigarette smoke on progression of oral cancer and its related chemoresistance. Her other projects involve studying the role of miRNA in cancer with relation to cigarette smoke.

Major Research Areas

	Proteomics approaches to identify biomarkers and therapeutic targets of lung, oral and esophageal squamous cell carcinoma
	Phosphoproteomic approaches to investigate aberrant regulation of kinase signalling pathways in cancers
	Role of miRNA in cancer progression

Publications

Research papers: 23; Review articles: 2;

Ogawa,T., Liggett, T.E., Melnikov,A.A., Monitto, C.L., Kusuke, D., Shiga, K., Kobayashi, T., Horii, A., Chatterjee, A., Levenson, V. V., Koch, W., Sidransky, D. and Chang, X. Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance. Cell Cycle, 2012, 11(8), 1-8.

Bhattacharjee, M., Raju, R., Radhakrishnan, A., Nanjappa, V., Muthusamy, B., Singh, K., Kuppusaami, D., Lingala, B. T., Pan, A., Mathur, P. P., Harsha, H. C., Prasad, T. S. K., Atkins, G. J., Pandey, A. and Chatterjee, A.* (2012). A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. Journal of Signal Transduction. In press. (* Corresponding Author)

Chang, X., Ravi, R., Pham, V., Bedi, A., Chatterjee, A.* and Sidransky, D. Adenylate Kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance. 2011. PLOS One.e20806.
(* Corresponding Author). [PubMed]

Chatterjee, A., Dasgupta, S. and Sidransky, D. Mitochondrial Subversion in Cancer. Cancer Prevention and Research (Phila). 2011. 4, 638-654. [PubMed]

Sen, T., Sen, N., Brait, M., Begum, S., Chatterjee, A., Hoque, M. O., Ratovitski, E. and Sidransky D. ΔNp63α confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation. Cancer Research. 2011. 71, 1167-1176. [PubMed]

Sen, T., Chang, X., Sidransky, D. and Chatterjee, A.* Regulation of ΔNp63α by NF-κB Cell Cycle. 2010. 9, 4841-4847. (Selected for News and Views). (* Corresponding Author). [PubMed]

Chatterjee, A., Chang, X., Sen, T., Ravi, R., Bedi, A. and Sidransky, D. Regulation of p53 Family Member Isoform ΔNp63α by the Nuclear Factor-κB Targeting Kinase IκB Kinase-β. Cancer Research. 2010. 70, 1419-1429. [PubMed]

Chatterjee, A., Sen, T., Chang, X. and Sidransky, D. Yes-associated protein 1 regulates the stability of ΔNp63α. Cell Cycle. 2010. 9, 162-167.[PubMed]

Chatterjee, A., Upadhyay, S., Chang, X., Nagpal, K. J., Trink, B. and Sidransky, D. U-box-type Ubiquitin E4 ligase, UFD2a Attenuates Cisplatin Mediated Degradation of ΔNp63α. Cell Cycle. 2008. 7, 1231-1237. [PubMed]

Chatterjee, A., Chang, X., Nagpal, K. J., Chang, S., Upadhyay, S., Califano, J.A., Trink, B. and Sidransky, D. Targeting Human 8-Oxoguanine DNA Glycosylase (hOGG1) to mitochondria protects cells from 2-methoxyestradiol-induced mitochondria dependent apoptosis. Oncogene. 2008. 27, 3710-3720. [PubMed]

Zhou, S., Kachhap, S., Sun, W., Wu, G., Chuang, A., Poeta, L., Grumbine, L., Mithani, K. S., Chatterjee, A., Koch, W., Westra, H. W., Maitra, A., Glazer, C., Carducci, M., Sidransky, D., McFate, T., Verma, A. and Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proceedings of National Academy of Science, U S A. 2007. 104, 7540-7545. [PubMed]

Upadhyay,S.*, Chatterjee, A.*, Trink, B., Sommer, M., Ratovitski , E. and Sidransky, D. TAp63γ regulates OGG1 and repair of oxidative damage in cancer Cell Lines. Biochemical and Biophysical Research Communications. 2007. 356, 823-828. (* Equal contribution). [PubMed]

Wu,G., Guo, Z., Chatterjee, A., Huang, X., Rubin, E., Wu, F., Mambo, E., Chang, X., Osada, M., Sook Kim, M., Moon, C., Califano, A.J., Ratovitski, E., Gollin, S.M., Sukumar, S., Sidransky, D. and Trink,B. Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast. Cancer Research. 2006. 66, 9829-9836. [PubMed]

Chatterjee, A., Mambo, E., Zhang, Y., DeWeese, T. and Sidransky, D. Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. BMC Cancer. 2006. 6, 235. [PubMed]

Upadhyay, S., Liu, C., Chatterjee, A., Hoque, M.O., Sook Kim, M., Engles, J., Westra, W., Trink, B., Ratovitski, E. and Sidransky, D. LKB1/STK11 suppresses COX-2 induction and cellular invasion through PEA3 in lung cancer. Cancer Research. 2006. 66, 7870-7879.[PubMed]

Hoque, M.O., Begum, S., Topaloglu, O., Chatterjee, A., Rosenbaum, E., Criekinge, W.V., Westra, W., Schoenberg, M., Zahurak, M., Goodman, S.N. and Sidransky, D. Quantitation of promoter methylation of multiple genes in unine DNA and bladder cancer detection. Journal of the National Cancer Institute. 2006. 98, 996 – 1004. [PubMed]

Chatterjee, A., Mambo, E. and Sidransky, D. Mitochondrial DNA mutations in human cancer. Oncogene. 2006. 25, 4663-4674. [PubMed]

Zhang, H., Chatterjee, A. and Singh, K. K. Saccharomyces cerevisiae polymerase {zeta} functions in mitochondria. Genetics. 2006. 172, 2683-2688. [PubMed]

Chatterjee, A., Mambo, E., Osada, M., Upadhyay, S. and Sidransky, D. The Effect of p53 RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity. FASEB J. 2006. 20, 112-114. [PubMed]

Kim, M.M., Glazer, C., Mambo, E., Chatterjee, A., Zhao, M., Sidransky,D. and Califano, J.A. Head and neck cancer cell lines exhibit differential mitochondrial repair deficiency in response to 4NQO. Oral Oncology. 2006. 42, 201-207. [PubMed]

Mambo, E.*, Chatterjee, A.*, Xing, M., Tallini, G., Haugen, B.R., Yeung, S., Sukumar, S. and Sidransky, D. Tumor-specific Changes in mtDNA Content in Human Cancer. International Journal of Cancer. 2005. 116, 920-924. (* Equal contribution) .[PubMed]

Mambo, E.*, Chatterjee, A.*, Souza-Pinto, N., Mayard, S., Hogue, B.A., Hoque, M.O., Dizdaroglu, M., Bohr, V.A. and Sidransky,D. Oxidized Guanine Lesions and hOgg1 Activity in Lung Cancer. Oncogene. 2005. 24, 4496-508. (* Equal contribution) . [PubMed]

Wu, G., Xing, M., Mambo, E., Huang, X., Liu, J., Guo, Z., Chatterjee, A., Goldenberg, D., Gollin, S.M., Sukumar, S., Trink,B. and Sidransky, D. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. Breast Cancer Research. 2005. 7, R609-616. [PubMed]

Rasmussen, A. K., Chatterjee, A., Rasmussen, L. J. and Singh, K. K. Mitochondria as determinant of genetic stability in Saccharomyces cerevisiae. Nucleic Acids Research. 2003. 31, 3909-3917. [PubMed]

Chatterjee, A. and Singh, K. K. Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype. Nucleic Acids Research. 2001. 29, 4935-4940. [PubMed]

Chatterjee, A., Kanjilal, S. and Bhattacharyya, A. K. Purification of human seminal acrosin inhibitor and its kinetics. Journal of Biosciences. 1999. 24, 323-328. [PubMed]

Scientific meetings attended

Poster presentation.
101st AACR Annual Meeting. April 17-21, 2010, Washington DC, USA.
Regulation of p53 Family Member Isoform ΔNp63α by the Nuclear Factor-κB Targeting Kinase IκB Kinase-β. Chatterjee, A., Chang, X., Sen, T., Ravi, R., Bedi, A., and Sidransky,D.

Poster presentation.
99th AACR Annual Meeting. April 12-16, 2008, San Diego, California, USA.
Targeting Human 8-Oxoguanine DNA Glycosylase (hOGG1) to mitochondria protects cells from 2-methoxyestradiol-induced mitochondria dependent apoptosis. Chatterjee, A., Chang, X., Chang, S., Upadhyay, S., Califano, J.A. and Sidransky, D.

Poster presentation
98th AACR Annual Meeting . April 14-18, 2007, Los Angeles, California, USA.
TAp63y regulates hOgg1. Upadhyay,S*., Chatterjee, A.*, Trink, B., and Sidransky, D.
* Equal Contribution

Poster presentation
95th AACR Annual Meeting. March 26-31, 2004 at Orlando, Florida, USA.
The Role of Mutant hogg1 in Mitochondrial DNA Repair. Chatterjee, A., Mambo, E., and Sidransky, D.

Poster presentation
6th International Conference on Head and Neck Cancer. August 7-11, 2004 at Washington, D.C, USA.
Head and Neck Cancer Cell Lines Exhibit Repair Deficiency when Exposed to an Oxidative Damaging Agent. Kim, M.M., Mambo, E., Chatterjee, A., Sidransky, D., and Califano, J.A.

Poster presentation
Johns Hopkins Comprehensive Cancer Centre, Fellow Research Day. April 2001 at Baltimore, Maryland, USA.
Mechanisms of mitochondrial DNA mutagenesis. Chatterjee, A., Sigala, B., Sikder,H.A., and Schwimmer, C., and Singh, K.K.

Invited Lecture
3rd National Congress on Assisted Reproductive Technology and Advances in Infertility Management.
February 1997 at Calcutta, India.
Acrosin Proacrosin System. Chatterjee, A.

Invited Lecture
Young Scientists Symposium on Frontiers of Reproductive Biology. Organised by Indian Council of Medical Research, March 1996 at Hyderabad, India.
Human Proacrosin: Studies on activation and inhibition. Chatterjee, A.

Associations

	Guest Editor - Special Issue Journal of Oncology on “Cigarette smoke and Cancer” (2010-2012)
	Reviewer- PLOS One, Journal of Proteomics, FEBS Letters, Hematological Oncology
	Member-American Association for Cancer Research